GHK-Cu, a tripeptide with the amino acid sequence Gly-His-Lys, has a molecular formula of C₁₄H₂₄N₆O₄Cu and a molar mass of approximately 340.82 g/mol. Research-grade GHK-Cu is typically characterized by a purity of at least 98% as determined by high-performance liquid chromatography (HPLC) and is often provided with a Certificate of Analysis (CoA) that includes details on the material’s identity, purity, and other relevant specifications. When sourcing GHK-Cu for laboratory research, it is essential to verify the purity and authenticity of the material by reviewing the CoA and ensuring that it meets the required standards for research use.
Chemical Identity and Classification
GHK-Cu is a synthetic tripeptide that is often used as a reference material in laboratory research. Its chemical structure consists of a copper ion coordinated to the amino acid sequence Gly-His-Lys, which is typically synthesized through solid-phase peptide synthesis. The resulting material is a white or off-white powder that is soluble in water and other aqueous solvents.
Molecular and Structural Properties
The molecular properties of GHK-Cu are characterized by its molecular formula and molar mass, as well as its structural properties, which include its amino acid sequence and copper coordination. The material’s physical characteristics, such as its appearance, solubility, and stability, are also important considerations for laboratory research. A comparison of the molecular properties of GHK-Cu with other related compounds is shown in the following table:
| Compound |
Molecular Formula |
Molar Mass (g/mol) |
Purity (%) |
| GHK-Cu |
C₁₄H₂₄N₆O₄Cu |
approximately 340.82 |
>= 98% |
Physical Characteristics and Handling
GHK-Cu is typically provided as a lyophilized powder that is stable at room temperature when stored in a dry, aseptic environment. The material should be handled using aseptic laboratory technique to prevent contamination and degradation. When preparing research stock solutions, it is recommended to use sterile water and pipetting techniques to minimize the risk of contamination.
Purity and Quality Verification
The purity and quality of GHK-Cu can be verified by reviewing the Certificate of Analysis (CoA) provided by the supplier. The CoA should include details on the material’s identity, purity, and other relevant specifications, such as its molecular formula, molar mass, and HPLC purity. Research-grade GHK-Cu should have a purity of at least 98% as determined by HPLC. For example, research-grade compounds from reputable suppliers like Alpha Amino are provided with a per-lot CoA that includes these details.
Selecting and Verifying a Research-Grade Source
When selecting a supplier of research-grade GHK-Cu, it is essential to verify the quality markers of the material, including its purity, identity, and authenticity. A reputable supplier should provide a per-lot CoA that includes details on the material’s specifications, as well as transparent lot numbers and US-based sourcing. Alpha Amino, a US-based supplier of laboratory research chemicals, provides research-grade GHK-Cu that meets these standards, with a per-lot CoA and HPLC purity of at least 98%.
Frequently asked questions
What is the typical purity of research-grade GHK-Cu?
Research-grade GHK-Cu typically has a purity of at least 98% as determined by HPLC. This level of purity is essential for laboratory research applications, where the accuracy and reliability of the results depend on the quality of the reference materials used.
How can I verify the authenticity of GHK-Cu?
The authenticity of GHK-Cu can be verified by reviewing the Certificate of Analysis (CoA) provided by the supplier, which should include details on the material’s identity, purity, and other relevant specifications. Additionally, the supplier should provide transparent lot numbers and US-based sourcing to ensure the material’s authenticity.
What are the key considerations when selecting a supplier of research-grade GHK-Cu?
When selecting a supplier of research-grade GHK-Cu, it is essential to consider the quality markers of the material, including its purity, identity, and authenticity. The supplier should provide a per-lot CoA, transparent lot numbers, and US-based sourcing to ensure the material’s quality and reliability.
How should GHK-Cu be handled and stored in the laboratory?
GHK-Cu should be handled using aseptic laboratory technique to prevent contamination and degradation. The material should be stored in a dry, aseptic environment at room temperature, and research stock solutions should be prepared using sterile water and pipetting techniques to minimize the risk of contamination.
What is the importance of a Certificate of Analysis (CoA) when purchasing research-grade GHK-Cu?
A Certificate of Analysis (CoA) is essential when purchasing research-grade GHK-Cu, as it provides details on the material’s identity, purity, and other relevant specifications. The CoA ensures that the material meets the required standards for research use and provides a level of quality control and assurance.
Alpha Amino products are sold strictly for laboratory and research use only and are not intended for human or veterinary use, diagnosis, treatment, or consumption.
